|Occupation||President of Tri-Psi Sorority|
| Powers and|
|Several Vampire-like Abilities|
|Played By||Brooke Nevin|
- "Welcome to the most prestigious and exclusive sorority ever at Metropolis University. We are the richest. We are the prettiest. We are the best. Over the next few days, many of you will be disappointed, but if you are insanely cool and very, very lucky, you might just be chosen to be a Tri Psi and if that happens, it'll change your life forever."
- —Buffy to the Tri-Psi pledges. [src]
Buffy Sanders was the president of the Tri-Psi sorority at Metropolis University. At some point before joining the sorority, Buffy was trapped in a bat cave infected with Kryptonite-irradiated stalactites. After being bitten, she mutated into a metahuman with vampire-like traits.
Powers and Abilities
The saliva of the Kryptonite-infected vampire bats caused mutations in Buffy's body. This - combined with the bat's DNA - endowed Buffy with enhanced physical traits as well as vampiric characteristics such as an aversion to light, elongated canines, and cannibalistic tendencies.
- Super-Strength - As an added benefit of her infection, Buffy's muscles exerted inhuman force to a notably limited degree. While she couldn't match the likes of a mature Kryptonian or most other powerful metas, she was strong enough to slap Lana across a room - snapping her body in several places.
- Healing Factor - Although her body could still sustain injuries, Buffy's cells could regenerate themselves at exceptionally fast rates and with far more permanence than any uninfected human - to such an extent that she could recover from several dislocated bones and even a broken neck in seconds.
- Longevity - While the accuracy of this claim was never proven, Buffy claimed that Lana - and by extension, the rest of the Tri-Psi pledges - would live forever. It's most likely this was merely a misconception centering on the idea that vampires are immortal as well as their ability to heal.
- Super-Speed - While not as fast as a mature Kryptonian or a user of the Speed Force, Buffy's mutation afforded her a limited degree of hyper-accelerated human speed. This allowed her to appear and disappear from a scene in an instant without being caught and possibly to catch any fleeing prey.
- Super-Smell - Buffy could smell blood from afar.
- Power Leech - By drinking the blood other metahumans or extraterrestrials, Buffy could metabolize some of their powers. While Buffy herself never exhibited this trait, this ability was shown when Lana - whom she infected - drank some of Clark's Kryptonian blood and inherited some of his power.
- Infectious Bite - As part of her mutation, Buffy's saliva carried a rabbis-like virus which - when introduced into the bloodstream of a victim through bites - would attack their red blood cells and prevent them from regenerating. This infection could only be treated with the Project 1138 antidote.
- Infectious Blood - Due to the blood-borne nature of her mutation, Buffy could infect or "turn" other humans into vampires like herself by forcing them to ingest her blood. This trait was inherited by her sisters as well. It was never shown if her blood could convert extraterrestrials such as Clark.
- Sunlight - While not deadly, a side-affect of the disease - being rooted in the genetics of vampire bats - meant that Buffy inherited a nocturnal aversion to direct sunlight. This seemed only to be a moderate irritant to her eyesight (corrected with sunglasses) and did no harm to her flesh.
- Project 1138 Serum - LuthorCorp's Project 1138 was able to synthesize a cure for the vampire-like virus using Kryptonite-irradiated stalactites to keep the serum active. Had it been administered directly into her heart, it would have reversed the affects of the disease and rendered Buffy fully human.
- Heat Vision - Despite her regenerative capabilities and apparent immortality, Buffy was not invincible. Her body was instantly and completely incinerated after Lana - having fed upon Clark's blood and thus absorbed some of his power - used heat vision on Buffy when she was about to attack her.
Lana was forced to pledge Tri-Psi in order to find housing, since she had been accepted to Metropolis University so late. However, after she was accepted, Buffy revealed to her that the sorority sisters were actually vampires and turned Lana into a vampire by cutting her own tongue and making Lana drink her blood with a kiss. While doing some digging for her story for Pauline Kahn, Chloe discovered that none of the girls who joined Tri-Psi left after joining and also that a Smallville girl, Buffy Sanders, had been trapped in a cave full of bats and was rescued by LuthorCorp. When Clark later talked to Lex about this, he revealed that kryptonite had been in the cave walls, mutating all animal and plant life in the cave. In the case of the bats, they were vampire bats affected by the kryptonite and bitten Buffy, who was infected with a strange strain of rabies that turned her into a vampire.
Later, Chloe and Clark attended a Tri-Psi Halloween party to find Lana, who was caught by Chloe dancing a little too close with another guy. She confronted Lana about this and Lana bit her, but Clark came to her rescue. Buffy saw that Clark had seen Lana bite into Chloe and threatened to have the sorority feed on Lana unless she brought Clark back to them as a meal. Lana succeeded in doing this by biting into Clark while he was visiting Lex and in the process gained his strength and heat vision. Later, when the sorority sisters were about to feed on Clark, Lana stopped them, saying that he was not a normal guy and suggested that they turn him instead. This angered Buffy, who faced off with Lana, but Lana promptly incinerated her with a blast of heat vision.
- Buffy's name is a parodist homage to Buffy Summers, the titular character of both the film and subsequent television series Buffy the Vampire Slayer - the latter of which the Smallville series overall draws heavy inspiration from in terms of both themes and character development.
- "Buffy Sanders" is not her real name: in Chloe's article describing the Tri-Psi sorority, she mentions that she has "changed the names to protect the vapid".
- Also relating to Buffy the Vampire Slayer, James Marsters plays a part in the episode as Clark's professor. While Chloe is in the hospital he stops by stating that "vampires are not real" making it ironic, as he himself played Spike (a vampire) on Buffy and its spin-off show Angel.