Main article: Kryptonite
Kryptonite is a mineral from Clark's home planet Krypton. According to some comics, kryptonite was created when the core of Krypton became radioactive just before it exploded, but in Smallville it was also placed in Asia, presumably by Clark's ancestor 500 years ago, suggesting that it might be a natural occurring radioactive element from Krypton. The known variations of kryptonite affect Clark in different ways. Fortunately, for external exposure, Clark can protect himself from kryptonite using lead and removal of the substance reverses the effects almost immediately. If it gets into his system, his body forces it out via perspiration.
- Green kryptonite is Clark's most severe and dangerous vulnerability. Green K in any size or form renders Clark powerless and painfully incapacitated; he once remarked that broken ribs hurt less than green K exposure. When Clark is exposed to green K, his veins become dark and prominent, he sweats profusely, his vision blurs, and he clutches his stomach as if nauseated; it is shown that his blood literally appears to boil. He can barely stay on his feet and usually collapses to the ground in agony. Prolonged exposure renders him unconscious and would probably kill him. Clark can draw blood or bruise while in the presence of green K. Since the meteor shower, it is found in abundance in Smallville and Clark has fallen ill or passed out from ingestion, inhalation, and close proximity to green K. Clark's weakness to green kryptonite started at least as early as grade school; however, he did not figure out the connection with the meteor rocks until his teens, saying he is "allergic" to them. Clark and his parents keep a green meteor rock in a lead box in case they ever had to subdue him in an emergency. It has been shown that even a simple layer of lead between Clark and the kryptonite is enough to prevent Clark feeling the effects of kryptonite bullets, while lead paint proves sufficient protection from conventional meteor rocks. While kryptonite weakens Clark's powers, he has been shown to still be able to use his abilities in its presence, although it takes more effort for him to use them (Source episodes: Pilot, Metamorphosis, Leech, Phoenix, Extinction, Obsession, Onyx and Splinter)
- Red kryptonite makes Clark lose his inhibitions and social conscience. Similar to the effects of alcohol, Clark becomes Kal, who is unpredictable and belligerent. On red K, Clark is also sexually aggressive (though apparently not sexually active), flirtatious, and unconcerned with keeping his abilities a secret. He is disrespectful, uncaring of others' feelings, and can become violently dangerous. Clark also rarely swears unless under the influence of red K. (Source episodes: Red, Rush, Exodus, Exile, Unsafe and Crimson)
- Blue kryptonite strips Clark of his powers, but not painfully-so like green K; simply coming in contact with it appears to merely shut his powers down until he is no longer touching it. (Source episode: Blue)
- Black kryptonite can separate or combine Clark from/with his Kryptonian personality, Kal-El. Black K works on humans as well, physically splitting them into their good and evil personas. (Source episodes: Crusade and Onyx)
- Silver kryptonite makes Clark extremely paranoid and suspicious of those around him. Silver K's effects on Clark are similar to those of hallucinogenic drugs. His behavior becomes erratic and he suffers extremely vivid visual and auditory hallucinations, such as perceiving balance sheets as bills. In addition, Clark manifests physical symptoms such as sweating, labored breathing, and puffy, dilated eyes, although his powers are unaffected. (Source episode: Splinter)
| Clark beaten and weakened by green kryptonite beads.
Clark is uninhibited while exposed to red kryptonite.
Clark is split in two by black kryptonite.
Silver kryptonite makes Clark paranoid.
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