|Family||Ted Sanders (father) Betty Sanders (mother), two ex-husbands (deceased), Lex Luthor (ex-husband)|
|Occupation||Biology teacher (Smallville High School)|
| Powers and|
|Played By||Krista Allen|
Powers and AbilitiesEdit
- Super pheromones: Desirée was a teenager in Smallville during the 1989 meteor shower. She was with her boyfriend in an intimate moment when the meteors struck: as a result, she acquired the ability to generate meta-human pheromones and emit them from her mouth in the form of a purple mist: once the pheromones were inhaled by her target they would become instantly infatuated with her and vulnerable to her command. She was able to seduce multiple targets concurrently. Only human men were demonstrated to be vulnerable to her meta-human pheromones.
Her boyfriend killed her parents and she inherited their fortune. Five years later, she married a wealthy man and became a schoolteacher, but one of her students killed her husband. Again, she inherited a great deal of money, but she lost it in bad investments.
She managed to seduce and marry Lex Luthor, continuing her pattern. She got a job as a biology teacher at Smallville High, intending to duplicate her previous pattern by having one of her students kill Lex for her. However, she failed to seduce Clark Kent, his Kryptonian nature rendering him immune to her abilities, forcing her to frame him for arson, exploiting some of the accidents he had caused with his recently developed heat vision, as well as then used her powers to convince Jonathan Kent to kill Lex by convincing Jonathan that Lex was hurting her. Clark was able to use his heat vision to save Lex by melting the bullet from his father's gun mid-flight and Desirée was sent to prison. 
Her marriage to Lex was annulled.  She is currently still in prison for attempted murder. 
- Desirée means "desired", likely alluding to her powers.