Whitney and Lana nearly got caught in the explosion themselves and Lana was knocked off her feet. Deputy Gary Watts kidnapped and fired a bullet at Lana to take the credit for solving her murder. Clark arrived in time to deflect the bullet.
Ian Randall split himself in two and attempted to kill both Chloe and Lana by throwing them off a dam. Clark caught Chloe, knocked one Ian out, pulled Lana to safety, and let the other Ian fall off the dam.
Lana brought food to the Smallville Stables for a mentally ill Lex, but he became angry, accused her of attempting to drug him, and threw her into a horse stall. The horse was spooked and trampled on her, breaking her leg.
As an adolescent, Emily Dinsmore escaped confinement and took a second attempt on Lana's life, concealing her in a glass room which she gassed with chlorine. Clark busted through the glass walls to save her.
Lana was infected with a lethal toxin which caused people to live their worst fear before putting them into a coma. Clark super-heated Lex's antidote so it could be distributed to the victims of the toxin.
In an attempt to re-create high school, Brendan Nash kidnapped Lana along with several other students, using his meteor power to threaten them into participating in school activities. When Clark defeated Brendan, everyone who was frozen went back to normal.
Under the influence of silver kryptonite, Clark almost choked Lana to death after hallucinating that she was having an affair with Lex. Milton Fine removed the splinter of silver kryptonite from Clark, saving Lana in the process.
While being pursued by a drunk Lex, Lana died when her SUV was hit by a bus. Distraught over her death, Clark went to the Fortress of Solitude and asked Jor-El to reverse time, saving her from the car accident.
Lana was nearly killed when Tess Mercer attacked the machinery that was keeping her alive while the Prometheus Suit was applied to her skin but Dr. Groll knocked Tess away so she didn't have a clear shot.
Lana's life has been at risk 50 times over the course of the show until her departure in Requiem.
Lana Lang has died in four episodes on the show (Reckoning, Lexmas, Void, and Noir). Arguably, her deaths in Lexmas and Noir do not count as they were during dream sequences. Also, her death in Reckoning was reversed so that it never actually happened in this timeline.
During Lex's dream sequence, Lana went into labor and started to rapidly lose blood. Lionel refused to help; as a result, Lana died. (Lexmas)
Lana is almost killed by a fellow beauty pageant (Mrs. Smallville) contestant Holly Gehrig (who has the ability of acid touch) due to Holly's obsession of winning. Lana's saved by the arrival of Clark and Chloe.