At the charity gala in the Luthor Hall Collection of the Metropolis Museum, Clark Kent and Lex Luthor admire a piece of jewelry-encrusted armor that belonged to Alexander the Great. The jewelry on the breastplate appear to be ruby red and blue sapphire, also their's snake like pattern on the chest, shaped like an S in the centre.
Lana Lang is also there, but when she invites Clark to join her and her boyfriend Whitney Fordman, he retreats to get some air. Outside the museum, Detective Sam Phelan a police officer is beating someone up, ranting about obtaining his file at internal affairs. As Clark walks down the steps of the museum, a bus comes around a corner. When the driver has a heart attack, the bus starts plowing through the parked cars along the side of the road. Just before the bus crashes into a bus stop where a man is sleeping, Clark uses his super speed and his super strength to get in front of the bus and let it crash into him.
Later, Phelan takes Clark to the museum. He wants him to steal the breastplate for him. They disable the security system and call in a bomb threat to get the guards out. Lex finds a plain brown package in the newspaper dispenser. He opens it up to find an alarm clock inside. Inside the museum, Clark bends the bars and breaks the glass protecting the breastplate. Phelan places the breastplate in a duffel bag and Clark throws it through a window to land at the feet of the guards on the sidewalk. Enraged by this double cross, Phelan pulls out his gun and fires. Clark uses his super speed to dodge the bullet. When the guards reenter the museum, Phelan fires at them and they shoot him down.
Lex reviewed security footage of the museum in which Clark appeared as a blur.
Oliver is taking a tour of the Metropolis Museum while discussing with its curator, Adrianna, on his big entrance as Green Arrow. Adrianna talks about how she wants to put him on a harness and helmet much to Oliver's dismay, when Tess comes in and pokes fun at Oliver, saying that he is nothing more than a caricature of himself and wonders what he is up to. Oliver responds by asking her whether or not she even knows real love anymore. After speaking to an employee, Adrianna informs Oliver and Tess that the amulet of Isis is missing from the show's pieces; she also tell them that the amulet is cursed and whoever posses it is doomed to spend eternity in the underworld.
At the museum, Cat is snooping around and sees Isis/Lois rip open a metal door and send a security guard flying. Isis/Lois heads towards the crate containing Osiris' heart and rips off the lid. Cat declares that she won't let Lois get away with another crime and begins to take a picture of her. Clark arrives and speeds Cat away to a café as she takes a picture of a coffee mug instead. She stands up, clearly disoriented and confused. Clark returns to the museum to find the crate empty. As he leaves, he fixes the door Isis/Lois ripped open and speeds away while being watched by Isis/Lois.
Clark later came in and tells them that Isis/Lois has disappeared with the heart of Osiris, and both Tess and Oliver inform him that she might be headed for the Metropolis Museum to reunite Osiris' heart with his body. Tess tells them that she might know a way to get Isis out of Lois.
At the Metropolis Museum, Isis/Lois prepares to bring Osiris back to life, but she opens the sarcophagus only to find that it is full of dirt. She breaks down in tears just as Clark comes in and tells her it is over. Isis/Lois declares that it cannot be over because their love is eternal and that Clark knows nothing about love. Clark tells her that he does and that the woman that he loves is the vessel that she has taken over and her wants her back. Isis/Lois wonders if he would risk the world for her and notes that he holds himself back from her before telling him that if he won't sacrifice his heart then she will. She then proceeds to push him onto the sarcophagus and binds him down, getting ready to sacrifice him to Osiris.
Cat is sneaking around the Museum, looking for the "Blur", when she stumbles onto Isis/Lois performing the ritual to bring Osiris back. Shocked, she knocks a statue over and breaks it. Isis/Lois turns and Cat runs away when she bumps into Green Arrow, who then locks her inside a sarcophagus and proceeds to deal with Isis.
Isis/Lois senses Oliver behind her and notes that he is brave but lonely; she also notes that he doesn't want to hurt Lois' body and then throws an energy ball at him, which he dodges, Oliver reveals to Clark that the only way to trap Isis is for the sun to hit the amulet again, thus trapping her spirit. Isis again throws an energy ball at Oliver long enough for Clark to break free of his restraints and grab Osiris' heart. Clark threatens to destroy the heart unless Isis releases Lois. Isis/Lois, seeing no hope, asks Clark whether Lois loves him completely. She then tells him that because he has Osiris' heart, she will take Lois's, and attempts to stab herself. Oliver fires an arrow at the amulet, sending it towards Clark, who uses his heat vision on the amulet, retrapping Isis and freeing Lois. She collapses in Clark's arms, and asks him if they took a back tour of the museum. She then tells him she loves him and calls him a nerd.